However, the efficacy of this intervention is uncertain. Anti-inflammatory properties of its active metabolite are used for the justification of vitamin D 3 supplementation in MS to improve these outcomes. Low circulating levels of 25(OH)D predict a higher risk of relapses and active MRI lesions in several cohorts with early relapsing remitting multiple sclerosis (RRMS). Vitamin D 3 supplementation has a consolidated role in the promotion of a healthy bone metabolism in individuals with low circulating 25-hydroxyvitamin D (25(OH)D) levels. Abstract Category: Hot Topic 3: Should we recommend vitamin D supplementation to our MSÄ¡Department of Neurology, Canisius Wilhelmina Hospital, Nijmegen, 2Neuroimmunology researchgroup, Netherlands Institute for Neuroscience, Amsterdam, The Netherlands
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